I live in Panama City and have not been disappointed. I also started my research on Panama with International Living then added blogs, forums, videos, and anything I could find. When we were ready for the exploratory trip, we decided on staying in Panama City for a month as a home base to explore a few areas of consideration. If you do extensive research, you can narrow down the towns to explore when you visit.
By the time we were ready to check out Panama, we had already crossed Boquete off the list, from just the research. Panama City was not even on our list because PC does not always get a fair assessment from fellow expats. By spending time in PC and seeing for ourselves what Panama City had available, it was the only choice. There is so much to do in PC and the city always has surprises, like unexpected firework displays or trips to the grocery store turning into cultural events with music, dancers, and free wine & beer. Panama City is fantastic and I would not live anywhere else.
About the motorcycles....they are all over the city, avoiding the traffic. There are always 4-5 big bikes parked outside of my building. No one tickets them for parking on the concrete, as long as they do not park on the sidewalk. Dominoes Pizza and other foods are delivered on the smaller, scooter type bikes. There are several big bike dealers in Panama City. BMW has a store and sponsors bike trips of 1, 2, 5, and 8 days. You can take an 8 trip across Panama all the way to ChiriquÃ. I think it is called Motor Tours Panama. Harley has a big shop in PC, too. They get groups of bikers together and ride out to the beaches and mountains for fun.
You will manage with basic Spanish in Panama City. It is true that you really do need to know Spanish here. I am not fluent yet, but I just give it a go and I somehow always pull off what I need to do. Just learn the basics to start and then add to your vocabulary along the way. If you will be renting a car, study auto related words. If you are going to Subway for lunch, learn the menu. I am finding that I learn the words quicker if they are of interest and actual use, rather than book drills.
On the comment about Italy. My husband and I were originally planning to retire in Germany because we had lived they for many years. We love Panama even more. The people are warm, friendly, and kind and the country is beautiful.